Composition:
Each one gm contains:
Doxycycline hyclate…………..346.21 (Eq. to 300 mg doxycycline )
Properties:
Doxycycline is a bacteriostatic antibiotic belonging to the tetracycline group, which acts by inhibition of protein synthesis.
Doxycycline produce its bacteriostatic action by binding to the 30s ribosomal subunit of susceptible organisms.
After binding to the ribosome tetracyclines interfere with the binding of aminoacyl-t RNA to the messenger RNA-molecule/ribosome complex, thereby interfering with the bacterial protein synthesis in growing or multiplying organisms.
Tetracyclines mainly active against gram positive bacteria like streptococcus, staphylococcus and gram negative bacteria such as E.coli, Haemophilus paragallinarum, Pasteurella spp., and salmonella Tetracyclines are active against Mycoplasma and Rickettsia
Indications:
Broiler chickens:
Afridox is used in the treatment of:
Colibacillosis caused by Escherichia coli.*
* Chronic respiratory disease caused by Mycoplasma gallisepticum and Escherichia coli.
* Salmonellosis caused by Salmonella enteridis, Salmonella typhimurium.
* Pasterullosis caused by Pasteurella multocida infections.
Target species:
Broiler chickens.
Dosage& Route of administration:
Route of administration: orally via drinking water.
For whole product:
0.4 gm of Afridox /1 Litre of drinking water up to 5 days.
Warning & Precaution:
The daily dose should be added to the drinking water to be consumed in 24 hours. *
* Don’t use in chicken producing eggs for human consumption.
Contra –Indication:
* Absorption of chlortetracycline from the alimentary tract is reduced by calcium, iron, magnesium and zinc salts.
* Don’t use in chicken producing eggs for human consumption.
Side Effects:
Overdoses up to 1.6 times the label recommended dose resulted in no clinical signs that could be attributed to *
Poultry tolerate double overdoses of doxycycline (40 mg / kg body weight) without any clinical effect.*
* For longer treatments digestive disturbances may occur by intestinal dysbiosis
Withdrawal time:
Broiler chickens: 10 days.
Storage:
Stored at temperature not exceeding 30ْ c, in dry place and used immediately after opening and reconstitution.
